Frank Smith was the first settler in 1877. In 1880, a post office was established under the name Chipco, however it was discontinued after only a year. It was re-established under the name Micco in 1884.

In 1993, the post office was merged with the Sebastian post office. They are in two separate buildings next to one another, but one is merely a counterpart of the other.

Micco is mapped at 27°52′39″N 80°30′52″W / 27.87750°N 80.51444°W / 27.87750; -80.51444 (27.877504, −80.514578).

According to the United States Census Bureau, the CDP has a total area of 9.9 square miles (25.6 km2), of which 7.6 square miles (19.7 km2) is land and 2.2 square miles (5.8 km2), or 22.78%, is water.